Derrick Williams added 18 points and Nikola Pekovic had 14 for Minnesota. Jose Barea chipped in with seven assists.
Williams scored 13 points and Pekovic added 10 during an opening burst that gave the Timberwolves a 27-10 lead in the first quarter. Minnesota pushed its lead to 52-29 at the half.
The Pistons showed some life after the break, going on an 8-0 run to close the gap to five. Stuckey scored 13 third-quarter points after putting in eight in the opening half.
The Timberwolves bounced back to stretch their lead to 68-53 entering the fourth and were in control throughout the final quarter.