PITTSBURGH (AP) Senorise Perry rushed for 101 yards and a career-high four touchdowns to help No. 18 Louisville race by Pittsburgh 45-35 on Saturday.
Teddy Bridgewater passed for 304 yards for the Cardinals (6-0, 1-0 Big East), including a 75-yard score to Devante Parker on the first play of the second half as Louisville continued its best start since 2006.
Parker's score came in the middle of a 24-point burst by Louisville spanning the second and third quarters that turned a seven-point deficit into a 38-21 lead.
Tino Sunseri passed for 287 yards and two touchdowns but Pitt (2-4, 0-3) couldn't complete a late rally.
Trailing by 10 with 5 minutes to play, Pitt went for it on fourth down deep in Louisville territory rather than attempt a field goal. Sunseri's pass was off the mark and Perry finished off the Panthers with a 59-yard sprint down the left sideline.