Notre Dame improved to 11-7 (2-3 ACC) and dropped the Hokies to 8-9 (1-4) after their 70-63 victory.
K.J. McDaniels scored 14 points to lead Clemson to a 56-49 victory over Virginia Tech on Wednesday.
Jarell Eddie scored 13 of his 17 points in the first half and Virginia Tech used two runs before the intermission to bounce back from a crushing loss by drubbing Maryland-Eastern Shore 82-66 Tuesday.
Brett Hundley threw two touchdown passes and ran for two more scores to help No. 17 UCLA rout Virginia Tech 42-12 on Tuesday in the Sun Bowl.