Mike Green shares the team lead among defensemen with 12 points.
The Capitals had 76 shot attempts at the net on Saturday night. One went in.
Matt Niskanen scored an equalizer in the third period, but Torrey Mitchell gave the Sabres the 2-1 lead for good minutes later with his third goal of the season.
The Caps' Michael Latta squared off against Marcus Foligno in the first period.